Genome instability of ageing stem cells—Induction and defence mechanisms

Genome instability of ageing stem cells—Induction and defence mechanisms

The mammalian organism is comprised of tissue types with varying degrees of self-renewal and regenerative capacity. In most organs self-renewing tissue-specific stem and progenitor cells contribute to organ maintenance, and it is vital to maintain a functional stem cell pool to preserve organ homeostasis. Various conditions like tissue injury, stress responses, and regeneration challenge the st...

Ageing, defence mechanisms and the immune system.

Of all the systems in the body, the immune system is probably the best understood, both in mechanistic terms and in the ways in which it changes during ageing. Studies of the ageing immune system (immuno gerontology) can be traced back to the early part of this century (and even earlier), and the literature has burgeoned in the last three decades. Perhaps the first publication was of the invest...

The relationship between ageing and cancer: somatic mutations or break- down of host defence mechanisms.

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Persona and defence mechanisms.

Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma

Ongoing genomic instability represents a hallmark of multiple myeloma (MM) cells, which manifests largely as whole chromosome- or translocation-based aneuploidy. Importantly, although it supports tumorigenesis, progression and, response to treatment in MM patients, it remains one of the least understood components of malignant transformation in terms of molecular basis. Therefore these aspects ...